CD117

CD117
Функция	• protease binding; • protein tyrosine kinase activity; • transmembrane receptor protein tyrosine kinase activity; • receptor signaling protein tyrosine kinase activity; • stem cell factor receptor activity; • protein binding; • ATP binding; • cytokine binding; • protein homodimerization activity; • metal ion binding;
Компонент клетки	• acrosomal vesicle; • extracellular space; • plasma membrane; • external side of plasma membrane; • cytoplasmic side of plasma membrane; • integral component of membrane; • mast cell granule;
Биологический процесс	• activation of MAPK activity; • ovarian follicle development; • myeloid progenitor cell differentiation; • lymphoid progenitor cell differentiation; • immature B cell differentiation; • dendritic cell cytokine production; • mast cell chemotaxis; • glycosphingolipid metabolic process; • inflammatory response; • signal transduction; • epidermal growth factor receptor signaling pathway; • spermatogenesis; • spermatid development; • positive regulation of cell proliferation; • germ cell migration; • regulation of cell shape; • visual learning; • fibroblast growth factor receptor signaling pathway; • male gonad development; • positive regulation of gene expression; • positive regulation of phospholipase C activity; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptidyl-tyrosine phosphorylation; • cytokine-mediated signaling pathway; • stem cell maintenance; • signal transduction by phosphorylation; • lamellipodium assembly; • hemopoiesis; • T cell differentiation; • erythrocyte differentiation; • melanocyte differentiation; • positive regulation of cell migration; • positive regulation of pseudopodium assembly; • actin cytoskeleton reorganization; • mast cell cytokine production; • somatic stem cell maintenance; • embryonic hemopoiesis; • ectopic germ cell programmed cell death; • megakaryocyte development; • Fc receptor signaling pathway; • Fc-epsilon receptor signaling pathway; • Kit signaling pathway; • erythropoietin-mediated signaling pathway; • regulation of cell proliferation; • positive regulation of tyrosine phosphorylation of Stat1 protein; • positive regulation of tyrosine phosphorylation of Stat3 protein; • positive regulation of tyrosine phosphorylation of Stat5 protein; • negative regulation of programmed cell death; • mast cell degranulation; • positive regulation of MAPK cascade; • pigmentation; • positive regulation of phosphatidylinositol 3-kinase activity; • innate immune response; • positive regulation of Notch signaling pathway; • positive regulation of JAK-STAT cascade; • protein autophosphorylation; • neurotrophin TRK receptor signaling pathway; • phosphatidylinositol-mediated signaling; • regulation of developmental pigmentation; • somatic stem cell division; • positive regulation of long-term neuronal synaptic plasticity; • digestive tract development; • stem cell differentiation; • epithelial cell proliferation; • detection of mechanical stimulus involved in sensory perception of sound; • positive regulation of sequence-specific DNA binding transcription factor activity; • cell chemotaxis; • mast cell differentiation; • mast cell proliferation; • cellular response to thyroid hormone stimulus; • melanocyte migration; • melanocyte adhesion;
	Источники: Amigo / QuickGO

CD117
	0
Доступные структуры
Функция	• protease binding; • protein tyrosine kinase activity; • transmembrane receptor protein tyrosine kinase activity; • receptor signaling protein tyrosine kinase activity; • stem cell factor receptor activity; • protein binding; • ATP binding; • cytokine binding; • protein homodimerization activity; • metal ion binding;
Компонент клетки	• acrosomal vesicle; • extracellular space; • plasma membrane; • external side of plasma membrane; • cytoplasmic side of plasma membrane; • integral component of membrane; • mast cell granule;
Биологический процесс	• activation of MAPK activity; • ovarian follicle development; • myeloid progenitor cell differentiation; • lymphoid progenitor cell differentiation; • immature B cell differentiation; • dendritic cell cytokine production; • mast cell chemotaxis; • glycosphingolipid metabolic process; • inflammatory response; • signal transduction; • epidermal growth factor receptor signaling pathway; • spermatogenesis; • spermatid development; • positive regulation of cell proliferation; • germ cell migration; • regulation of cell shape; • visual learning; • fibroblast growth factor receptor signaling pathway; • male gonad development; • positive regulation of gene expression; • positive regulation of phospholipase C activity; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptidyl-tyrosine phosphorylation; • cytokine-mediated signaling pathway; • stem cell maintenance; • signal transduction by phosphorylation; • lamellipodium assembly; • hemopoiesis; • T cell differentiation; • erythrocyte differentiation; • melanocyte differentiation; • positive regulation of cell migration; • positive regulation of pseudopodium assembly; • actin cytoskeleton reorganization; • mast cell cytokine production; • somatic stem cell maintenance; • embryonic hemopoiesis; • ectopic germ cell programmed cell death; • megakaryocyte development; • Fc receptor signaling pathway; • Fc-epsilon receptor signaling pathway; • Kit signaling pathway; • erythropoietin-mediated signaling pathway; • regulation of cell proliferation; • positive regulation of tyrosine phosphorylation of Stat1 protein; • positive regulation of tyrosine phosphorylation of Stat3 protein; • positive regulation of tyrosine phosphorylation of Stat5 protein; • negative regulation of programmed cell death; • mast cell degranulation; • positive regulation of MAPK cascade; • pigmentation; • positive regulation of phosphatidylinositol 3-kinase activity; • innate immune response; • positive regulation of Notch signaling pathway; • positive regulation of JAK-STAT cascade; • protein autophosphorylation; • neurotrophin TRK receptor signaling pathway; • phosphatidylinositol-mediated signaling; • regulation of developmental pigmentation; • somatic stem cell division; • positive regulation of long-term neuronal synaptic plasticity; • digestive tract development; • stem cell differentiation; • epithelial cell proliferation; • detection of mechanical stimulus involved in sensory perception of sound; • positive regulation of sequence-specific DNA binding transcription factor activity; • cell chemotaxis; • mast cell differentiation; • mast cell proliferation; • cellular response to thyroid hormone stimulus; • melanocyte migration; • melanocyte adhesion;
	Источники: Amigo / QuickGO

CD117
	0
Доступные структуры
Функция	• protease binding; • protein tyrosine kinase activity; • transmembrane receptor protein tyrosine kinase activity; • receptor signaling protein tyrosine kinase activity; • stem cell factor receptor activity; • protein binding; • ATP binding; • cytokine binding; • protein homodimerization activity; • metal ion binding;
Компонент клетки	• acrosomal vesicle; • extracellular space; • plasma membrane; • external side of plasma membrane; • cytoplasmic side of plasma membrane; • integral component of membrane; • mast cell granule;
Биологический процесс	• activation of MAPK activity; • ovarian follicle development; • myeloid progenitor cell differentiation; • lymphoid progenitor cell differentiation; • immature B cell differentiation; • dendritic cell cytokine production; • mast cell chemotaxis; • glycosphingolipid metabolic process; • inflammatory response; • signal transduction; • epidermal growth factor receptor signaling pathway; • spermatogenesis; • spermatid development; • positive regulation of cell proliferation; • germ cell migration; • regulation of cell shape; • visual learning; • fibroblast growth factor receptor signaling pathway; • male gonad development; • positive regulation of gene expression; • positive regulation of phospholipase C activity; • positive regulation of phosphatidylinositol 3-kinase signaling; • peptidyl-tyrosine phosphorylation; • cytokine-mediated signaling pathway; • stem cell maintenance; • signal transduction by phosphorylation; • lamellipodium assembly; • hemopoiesis; • T cell differentiation; • erythrocyte differentiation; • melanocyte differentiation; • positive regulation of cell migration; • positive regulation of pseudopodium assembly; • actin cytoskeleton reorganization; • mast cell cytokine production; • somatic stem cell maintenance; • embryonic hemopoiesis; • ectopic germ cell programmed cell death; • megakaryocyte development; • Fc receptor signaling pathway; • Fc-epsilon receptor signaling pathway; • Kit signaling pathway; • erythropoietin-mediated signaling pathway; • regulation of cell proliferation; • positive regulation of tyrosine phosphorylation of Stat1 protein; • positive regulation of tyrosine phosphorylation of Stat3 protein; • positive regulation of tyrosine phosphorylation of Stat5 protein; • negative regulation of programmed cell death; • mast cell degranulation; • positive regulation of MAPK cascade; • pigmentation; • positive regulation of phosphatidylinositol 3-kinase activity; • innate immune response; • positive regulation of Notch signaling pathway; • positive regulation of JAK-STAT cascade; • protein autophosphorylation; • neurotrophin TRK receptor signaling pathway; • phosphatidylinositol-mediated signaling; • regulation of developmental pigmentation; • somatic stem cell division; • positive regulation of long-term neuronal synaptic plasticity; • digestive tract development; • stem cell differentiation; • epithelial cell proliferation; • detection of mechanical stimulus involved in sensory perception of sound; • positive regulation of sequence-specific DNA binding transcription factor activity; • cell chemotaxis; • mast cell differentiation; • mast cell proliferation; • cellular response to thyroid hormone stimulus; • melanocyte migration; • melanocyte adhesion;
	Источники: Amigo / QuickGO

Рецептор фактора роста тучных и стволовых клеток (SCFR), или белковая тирозинкиназа Kit (CD117) — рецепторная тирозинкиназа, продукт гена KIT.^[1] Существует несколько изоформ белка.^[2] Впервые описан в 1987 году.^[3]

CD117 является цитокиновым рецептором, экспрессирован на поверхности гематопоэтических стволовых клеток, а также некоторых других клеток. Изменённые формы рецептора ассоциированы с некоторыми типами рака.^[4] CD117 является рецепторной тирозинкиназой III типа, рецептором для стволового фактора роста, т. н. лиганда "c-kit".

Связывание с лигандом приводит к димеризации рецептора и активации его внутренней тирозинкиназы, что приводит к активации сигнального пути, который играет роль в клеточном выживании, пролиферации и дифференцировке клеток.

CD117 взаимодействует со многими другими белками: APS , BCR, CD63, CD81, CD9, CRK, CRKL, DOK1, FES, GRB10, Grb2, KITLG, LNK, LYN, MATK, MPDZ, PIK3R1, PTPN11, PTPN6, STAT1, SOCS1, SOCS6, TEC.

↑ Andre C., Hampe A., Lachaume P., Martin E., Wang X.P., Manus V., Hu W.X., Galibert F. Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes (англ.) // Genomics : journal. — Academic Press, 1997. — January (vol. 39, no. 2). — P. 216—226. — doi:10.1006/geno.1996.4482. — PMID 9027509.
↑ Entrez Gene: KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (неопр.). Архивировано 7 марта 2010 года.
↑ Yarden Y., Kuang W.J., Yang-Feng T., Coussens L., Munemitsu S., Dull T.J., Chen E., Schlessinger J., Francke U., Ullrich A. Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand (англ.) // The EMBO Journal : journal. — 1987. — November (vol. 6, no. 11). — P. 3341—3351. — PMID 2448137. — PMC 553789.
↑ Edling C.E., Hallberg B. c-Kit--a hematopoietic cell essential receptor tyrosine kinase (англ.) // The International Journal of Biochemistry & Cell Biology : journal. — 2007. — Vol. 39, no. 11. — P. 1995—1998. — doi:10.1016/j.biocel.2006.12.005. — PMID 17350321.

Rossi, P. Transcriptional control of KIT gene expression during germ cell development. (англ.) // The International Journal of Developmental Biology : journal. — 2013. — Vol. 57, no. 2—4. — P. 179—184. — doi:10.1387/ijdb.130014pr. — PMID 23784828.
Liang, J.; Wu, YL.; Chen, BJ.; Zhang, W.; Tanaka, Y.; Sugiyama, H. The C-kit receptor-mediated signal transduction and tumor-related diseases. (англ.) // International Journal of Biological Sciences : journal. — 2013. — Vol. 9, no. 5. — P. 435—443. — doi:10.7150/ijbs.6087. — PMID 23678293.

Словарь онкологических терминов NCI. C-kit рецептор. (англ.)

[pmid9027509-1] Andre C., Hampe A., Lachaume P., Martin E., Wang X.P., Manus V., Hu W.X., Galibert F. Sequence analysis of two genomic regions containing the KIT and the FMS receptor tyrosine kinase genes (англ.) // Genomics : journal. — Academic Press, 1997. — January (vol. 39, no. 2). — P. 216—226. — doi:10.1006/geno.1996.4482. — PMID 9027509.

[entrez-2] Entrez Gene: KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (неопр.). Архивировано 7 марта 2010 года.

[pmid2448137-3] Yarden Y., Kuang W.J., Yang-Feng T., Coussens L., Munemitsu S., Dull T.J., Chen E., Schlessinger J., Francke U., Ullrich A. Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand (англ.) // The EMBO Journal : journal. — 1987. — November (vol. 6, no. 11). — P. 3341—3351. — PMID 2448137. — PMC 553789.

[pmid17350321-4] Edling C.E., Hallberg B. c-Kit--a hematopoietic cell essential receptor tyrosine kinase (англ.) // The International Journal of Biochemistry & Cell Biology : journal. — 2007. — Vol. 39, no. 11. — P. 1995—1998. — doi:10.1016/j.biocel.2006.12.005. — PMID 17350321.

[1]

[2]

[3]

[4]

Белки: Кластеры дифференцировки
1-50	CD1 (a-c, 1A, 1D, 1E) CD2 CD3 (γ, δ, ε) CD4 CD5 CD6 CD7 CD8 (a) CD9 CD10 CD11 (a, b, c, d) CD13 CD14 CD15 CD16 (A, B) CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 (A, B) CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 (a, b, c, d) CD43 CD44 CD45 CD46 CD47 CD48 CD49 (a, b, c, d, e, f) CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 (E, L, P) CD63 CD64 (A, B, C) CD66 (a, b, c, d, e, f) CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 (a, b) CD80 CD81 CD82 CD83 CD84 CD85 (a, d, e, h, j, k) CD86 CD87 CD88 CD89 CD90 CD91 CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 (a, b) CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 (a, b) CD121 (a, b) CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 (a, b, c) CD157 CD158 (a, d, e, i, k) CD159 (a, c) CD160 CD161 CD162 CD163 CD164 CD166 CD167 (a, b) CD168 CD169 CD170 CD171 CD172 (a, b, g) CD174 CD177 CD178 CD179 (a, b) CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 (a, b) CD212 CD213a (1, 2) CD217 CD218 (a, b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 (a, b) CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD270 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD319 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350
351-400	CD351 CD352 CD353 CD354 CD355 CD357 CD358 CD360 CD361 CD362 CD363 CD364 CD365 CD366 CD367 CD368 CD369 CD370 CD371

CD117

Функции

Взаимодействия

Примечания

Библиография

Ссылки

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