CD36

CD36
CD36
Идентификаторы
Псевдонимы	CD36, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3, CD36 molecule
Внешние ID	OMIM: 173510 MGI: 107899 HomoloGene: 73871 GeneCards: CD36
Расположение гена (человек)
Расположение гена (человек)
Хр.	7-я хромосома человека
Конец	80,679,277 bp
Расположение гена (Мышь)
Расположение гена (Мышь)
Хр.	5-я хромосома мыши
Конец	18,093,799 bp
Паттерн экспрессии РНК
Паттерн экспрессии РНК
	Наибольшая экспрессия в
	abdominal fat; ; subcutaneous adipose tissue;
	Наибольшая экспрессия в
	right lung lobe; ; left lung lobe; ; intercostal muscle;
	Дополнительные справочные данные
	Дополнительные справочные данные
Генная онтология
Генная онтология
Молекулярная функция	связывание с белками плазмы; low-density lipoprotein particle receptor activity; transforming growth factor beta binding; high-density lipoprotein particle binding; lipoprotein particle binding; thrombospondin receptor activity; lipid binding; low-density lipoprotein particle binding; lipoteichoic acid immune receptor activity; amyloid-beta binding; scavenger receptor activity; Toll-like receptor binding; oxidised low-density lipoprotein particle receptor activity; protein-containing complex binding;
Компонент клетки	аппарат Гольджи; apical plasma membrane; phagocytic vesicle; apical part of cell; brush border membrane; endocytic vesicle membrane; часть клеточной мембраны; мембрана; наружная сторона клеточной мембраны; часть мембраны; platelet alpha granule membrane; Липидный рафт; поверхность клетки; клеточная мембрана; внеклеточное пространство; specific granule membrane; внутренний компонент клетки; receptor complex;
Биологический процесс	low-density lipoprotein particle mediated signaling; apoptotic cell clearance; positive regulation of MAPK cascade; response to lipid; nitric oxide mediated signal transduction; intestinal absorption; positive regulation of blood microparticle formation; positive regulation of blood coagulation; plasma lipoprotein particle clearance; sensory perception of taste; cвёртывание крови; cellular response to hydroperoxide; positive regulation of ERK1 and ERK2 cascade; receptor internalization; cellular response to bacterial lipopeptide; amyloid fibril formation; cellular response to lipopolysaccharide; cell surface receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cholesterol transport; platelet degranulation; cholesterol import; cellular response to diacyl bacterial lipopeptide; negative regulation of transcription by RNA polymerase II; перенос; toll-like receptor TLR6:TLR2 signaling pathway; phagocytosis, recognition; cellular response to low-density lipoprotein particle stimulus; positive regulation of macrophage cytokine production; иммунный ответ; response to linoleic acid; negative regulation of gene expression; positive regulation of reactive oxygen species metabolic process; lipoprotein transport; positive regulation of cell-matrix adhesion; positive regulation of interleukin-12 production; triglyceride transport; long-chain fatty acid import into cell; MyD88-dependent toll-like receptor signaling pathway; response to fatty acid; regulation of removal of superoxide radicals; cellular response to lipoteichoic acid; positive regulation of cholesterol storage; intestinal cholesterol absorption; positive regulation of tumor necrosis factor production; Рецепторно-опосредованный эндоцитоз; липидный обмен; cGMP-mediated signaling; positive regulation of phagocytosis, engulfment; defense response to Gram-positive bacterium; positive regulation of cytosolic calcium ion concentration; positive regulation of interleukin-6 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; response to stilbenoid; positive regulation of NLRP3 inflammasome complex assembly; low-density lipoprotein particle clearance; lipid storage; positive regulation of macrophage derived foam cell differentiation; Агрегация клеток; toll-like receptor signaling pathway; neutrophil degranulation; regulation of lipid metabolic process; production of molecular mediator involved in inflammatory response; fatty acid metabolic process; phagocytosis, engulfment; response to bacterium; positive regulation of gene expression; positive regulation of cell death; cytokine-mediated signaling pathway; regulation of lipopolysaccharide-mediated signaling pathway; regulation of toll-like receptor signaling pathway; negative regulation of protein import into nucleus; regulation of protein heterodimerization activity; positive regulation of nitric oxide biosynthetic process; positive regulation of NF-kappaB transcription factor activity; energy homeostasis; regulation of action potential; positive regulation of cold-induced thermogenesis; cellular response to oxidised low-density lipoprotein particle stimulus; oxidised low-density lipoprotein particle clearance; amyloid-beta clearance by cellular catabolic process; positive regulation of reactive oxygen species biosynthetic process; cellular response to amyloid-beta;
	Источники: Amigo, QuickGO
Ортологи
Ортологи
	948
	12491
	ENSG00000135218
	ENSMUSG00000002944
	P16671
	Q08857
NM_000072; NM_001001547; NM_001001548; NM_001127443; NM_001127444;
	NM_001289908; NM_001289909; NM_001289911; NM_001371074; NM_001371075; NM_001371077; NM_001371078; NM_001371079; NM_001371080; NM_001371081
	NM_001159555; NM_001159556; NM_001159557; NM_001159558; NM_007643
NP_000063; NP_001001547; NP_001001548; NP_001120915; NP_001120916;
	NP_001276837; NP_001276838; NP_001276840; NP_001358003; NP_001358004; NP_001358006; NP_001358007; NP_001358008; NP_001358009; NP_001358010
	NP_001153027; NP_001153028; NP_001153029; NP_001153030; NP_031669
Смотреть (человек)	Смотреть (мышь)

CD36
CD36
Идентификаторы
Псевдонимы	CD36, BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3, CD36 molecule
Внешние ID	OMIM: 173510 MGI: 107899 HomoloGene: 73871 GeneCards: CD36
Расположение гена (человек)
Расположение гена (человек)
Хр.	7-я хромосома человека
Конец	80,679,277 bp
Расположение гена (Мышь)
Расположение гена (Мышь)
Хр.	5-я хромосома мыши
Конец	18,093,799 bp
Паттерн экспрессии РНК
Паттерн экспрессии РНК
	Наибольшая экспрессия в
	abdominal fat; ; subcutaneous adipose tissue;
	Наибольшая экспрессия в
	right lung lobe; ; left lung lobe; ; intercostal muscle;
	Дополнительные справочные данные
	Дополнительные справочные данные
Генная онтология
Генная онтология
Молекулярная функция	связывание с белками плазмы; low-density lipoprotein particle receptor activity; transforming growth factor beta binding; high-density lipoprotein particle binding; lipoprotein particle binding; thrombospondin receptor activity; lipid binding; low-density lipoprotein particle binding; lipoteichoic acid immune receptor activity; amyloid-beta binding; scavenger receptor activity; Toll-like receptor binding; oxidised low-density lipoprotein particle receptor activity; protein-containing complex binding;
Компонент клетки	аппарат Гольджи; apical plasma membrane; phagocytic vesicle; apical part of cell; brush border membrane; endocytic vesicle membrane; часть клеточной мембраны; мембрана; наружная сторона клеточной мембраны; часть мембраны; platelet alpha granule membrane; Липидный рафт; поверхность клетки; клеточная мембрана; внеклеточное пространство; specific granule membrane; внутренний компонент клетки; receptor complex;
Биологический процесс	low-density lipoprotein particle mediated signaling; apoptotic cell clearance; positive regulation of MAPK cascade; response to lipid; nitric oxide mediated signal transduction; intestinal absorption; positive regulation of blood microparticle formation; positive regulation of blood coagulation; plasma lipoprotein particle clearance; sensory perception of taste; cвёртывание крови; cellular response to hydroperoxide; positive regulation of ERK1 and ERK2 cascade; receptor internalization; cellular response to bacterial lipopeptide; amyloid fibril formation; cellular response to lipopolysaccharide; cell surface receptor signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cholesterol transport; platelet degranulation; cholesterol import; cellular response to diacyl bacterial lipopeptide; negative regulation of transcription by RNA polymerase II; перенос; toll-like receptor TLR6:TLR2 signaling pathway; phagocytosis, recognition; cellular response to low-density lipoprotein particle stimulus; positive regulation of macrophage cytokine production; иммунный ответ; response to linoleic acid; negative regulation of gene expression; positive regulation of reactive oxygen species metabolic process; lipoprotein transport; positive regulation of cell-matrix adhesion; positive regulation of interleukin-12 production; triglyceride transport; long-chain fatty acid import into cell; MyD88-dependent toll-like receptor signaling pathway; response to fatty acid; regulation of removal of superoxide radicals; cellular response to lipoteichoic acid; positive regulation of cholesterol storage; intestinal cholesterol absorption; positive regulation of tumor necrosis factor production; Рецепторно-опосредованный эндоцитоз; липидный обмен; cGMP-mediated signaling; positive regulation of phagocytosis, engulfment; defense response to Gram-positive bacterium; positive regulation of cytosolic calcium ion concentration; positive regulation of interleukin-6 production; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of I-kappaB kinase/NF-kappaB signaling; response to stilbenoid; positive regulation of NLRP3 inflammasome complex assembly; low-density lipoprotein particle clearance; lipid storage; positive regulation of macrophage derived foam cell differentiation; Агрегация клеток; toll-like receptor signaling pathway; neutrophil degranulation; regulation of lipid metabolic process; production of molecular mediator involved in inflammatory response; fatty acid metabolic process; phagocytosis, engulfment; response to bacterium; positive regulation of gene expression; positive regulation of cell death; cytokine-mediated signaling pathway; regulation of lipopolysaccharide-mediated signaling pathway; regulation of toll-like receptor signaling pathway; negative regulation of protein import into nucleus; regulation of protein heterodimerization activity; positive regulation of nitric oxide biosynthetic process; positive regulation of NF-kappaB transcription factor activity; energy homeostasis; regulation of action potential; positive regulation of cold-induced thermogenesis; cellular response to oxidised low-density lipoprotein particle stimulus; oxidised low-density lipoprotein particle clearance; amyloid-beta clearance by cellular catabolic process; positive regulation of reactive oxygen species biosynthetic process; cellular response to amyloid-beta;
	Источники: Amigo, QuickGO
Ортологи
Ортологи
	948
	12491
	ENSG00000135218
	ENSMUSG00000002944
	P16671
	Q08857
NM_000072; NM_001001547; NM_001001548; NM_001127443; NM_001127444;
	NM_001289908; NM_001289909; NM_001289911; NM_001371074; NM_001371075; NM_001371077; NM_001371078; NM_001371079; NM_001371080; NM_001371081
	NM_001159555; NM_001159556; NM_001159557; NM_001159558; NM_007643
NP_000063; NP_001001547; NP_001001548; NP_001120915; NP_001120916;
	NP_001276837; NP_001276838; NP_001276840; NP_001358003; NP_001358004; NP_001358006; NP_001358007; NP_001358008; NP_001358009; NP_001358010
	NP_001153027; NP_001153028; NP_001153029; NP_001153030; NP_031669
Смотреть (человек)	Смотреть (мышь)

CD36 — мембранный белок, экспрессированный на поверхности клеток нескольких типов, особенно макрофагах; относится к классу B скэвенджер-рецепторов, компонент системы врождённого иммунитета. Связывает эритроциты, заражённые паразитическим Plasmodium falciparum, окисленные липопротеины низкой плотности, фосфолипиды и жирные кислоты. Кроме этого, CD36, экспрессированный на поверхности эпителия вкусовых сосочков языка, является рецептором, связывающим жирные кислоты пищи и участвующим в формировании «вкуса жира».

Найден вкусовой рецептор, чувствительный к жиру

Hazen S.L. Oxidized phospholipids as endogenous pattern recognition ligands in innate immunity (англ.) // Journal of Biological Chemistry : journal. — 2008. — June (vol. 283, no. 23). — P. 15527—15531. — doi:10.1074/jbc.R700054200. — PMID 18285328.
Laugerette F., Passilly-Degrace P., Patris B., et al. CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions (англ.) // Journal of Clinical Investigation : journal. — 2005. — November (vol. 115, no. 11). — P. 3177—3184. — doi:10.1172/JCI25299. — PMID 16276419. — PMC 1265871.

[1]

[2]

[3]

[4]

Белки: Кластеры дифференцировки
1-50	CD1 (a-c, 1A, 1D, 1E) CD2 CD3 (γ, δ, ε) CD4 CD5 CD6 CD7 CD8 (a) CD9 CD10 CD11 (a, b, c, d) CD13 CD14 CD15 CD16 (A, B) CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 (A, B) CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 (a, b, c, d) CD43 CD44 CD45 CD46 CD47 CD48 CD49 (a, b, c, d, e, f) CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 (E, L, P) CD63 CD64 (A, B, C) CD66 (a, b, c, d, e, f) CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 (a, b) CD80 CD81 CD82 CD83 CD84 CD85 (a, d, e, h, j, k) CD86 CD87 CD88 CD89 CD90 CD91 CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 (a, b) CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 (a, b) CD121 (a, b) CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 (a, b, c) CD157 CD158 (a, d, e, i, k) CD159 (a, c) CD160 CD161 CD162 CD163 CD164 CD166 CD167 (a, b) CD168 CD169 CD170 CD171 CD172 (a, b, g) CD174 CD177 CD178 CD179 (a, b) CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 (a, b) CD212 CD213a (1, 2) CD217 CD218 (a, b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 (a, b) CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD270 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD319 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350
351-400	CD351 CD352 CD353 CD354 CD355 CD357 CD358 CD360 CD361 CD362 CD363 CD364 CD365 CD366 CD367 CD368 CD369 CD370 CD371

CD36

См.также

Примечания

Ссылки

Библиография