BMPR1A

BMPR1A
Функция	• RNA polymerase II transcription factor activity, sequence-specific DNA binding; • glycoprotein binding; • protein serine/threonine kinase activity; • transmembrane receptor protein serine/threonine kinase activity; • receptor signaling protein serine/threonine kinase activity; • protein binding; • ATP binding; • protein homodimerization activity; • SMAD binding; • metal ion binding;
Компонент клетки	• plasma membrane; • caveola; • external side of plasma membrane; • integral component of membrane; • dendrite; • neuronal cell body; • HFE-transferrin receptor complex;
Биологический процесс	• in utero embryonic development; • mesoderm formation; • somitogenesis; • Mullerian duct regression; • positive regulation of mesenchymal cell proliferation; • chondrocyte differentiation; • endocardial cushion formation; • transcription from RNA polymerase II promoter; • protein phosphorylation; • immune response; • transforming growth factor beta receptor signaling pathway; • ectoderm development; • dorsal/ventral axis specification; • positive regulation of pathway-restricted SMAD protein phosphorylation; • neural crest cell development; • stem cell maintenance; • pituitary gland development; • neural plate mediolateral regionalization; • signal transduction by protein phosphorylation; • lung development; • positive regulation of bone mineralization; • BMP signaling pathway; • hindlimb morphogenesis; • odontogenesis of dentin-containing tooth; • embryonic digit morphogenesis; • positive regulation of osteoblast differentiation; • positive regulation of transcription from RNA polymerase II promoter; • paraxial mesoderm structural organization; • lateral mesoderm development; • regulation of lateral mesodermal cell fate specification; • mesendoderm development; • embryonic organ development; • developmental growth; • positive regulation of epithelial cell proliferation; • negative regulation of neurogenesis; • palate development; • positive regulation of SMAD protein import into nucleus; • heart formation; • cellular response to BMP stimulus; • regulation of cellular senescence;
	Источники: Amigo / QuickGO

BMPR1A
	0
Доступные структуры
Функция	• RNA polymerase II transcription factor activity, sequence-specific DNA binding; • glycoprotein binding; • protein serine/threonine kinase activity; • transmembrane receptor protein serine/threonine kinase activity; • receptor signaling protein serine/threonine kinase activity; • protein binding; • ATP binding; • protein homodimerization activity; • SMAD binding; • metal ion binding;
Компонент клетки	• plasma membrane; • caveola; • external side of plasma membrane; • integral component of membrane; • dendrite; • neuronal cell body; • HFE-transferrin receptor complex;
Биологический процесс	• in utero embryonic development; • mesoderm formation; • somitogenesis; • Mullerian duct regression; • positive regulation of mesenchymal cell proliferation; • chondrocyte differentiation; • endocardial cushion formation; • transcription from RNA polymerase II promoter; • protein phosphorylation; • immune response; • transforming growth factor beta receptor signaling pathway; • ectoderm development; • dorsal/ventral axis specification; • positive regulation of pathway-restricted SMAD protein phosphorylation; • neural crest cell development; • stem cell maintenance; • pituitary gland development; • neural plate mediolateral regionalization; • signal transduction by protein phosphorylation; • lung development; • positive regulation of bone mineralization; • BMP signaling pathway; • hindlimb morphogenesis; • odontogenesis of dentin-containing tooth; • embryonic digit morphogenesis; • positive regulation of osteoblast differentiation; • positive regulation of transcription from RNA polymerase II promoter; • paraxial mesoderm structural organization; • lateral mesoderm development; • regulation of lateral mesodermal cell fate specification; • mesendoderm development; • embryonic organ development; • developmental growth; • positive regulation of epithelial cell proliferation; • negative regulation of neurogenesis; • palate development; • positive regulation of SMAD protein import into nucleus; • heart formation; • cellular response to BMP stimulus; • regulation of cellular senescence;
	Источники: Amigo / QuickGO

BMPR1A
	0
Доступные структуры
Функция	• RNA polymerase II transcription factor activity, sequence-specific DNA binding; • glycoprotein binding; • protein serine/threonine kinase activity; • transmembrane receptor protein serine/threonine kinase activity; • receptor signaling protein serine/threonine kinase activity; • protein binding; • ATP binding; • protein homodimerization activity; • SMAD binding; • metal ion binding;
Компонент клетки	• plasma membrane; • caveola; • external side of plasma membrane; • integral component of membrane; • dendrite; • neuronal cell body; • HFE-transferrin receptor complex;
Биологический процесс	• in utero embryonic development; • mesoderm formation; • somitogenesis; • Mullerian duct regression; • positive regulation of mesenchymal cell proliferation; • chondrocyte differentiation; • endocardial cushion formation; • transcription from RNA polymerase II promoter; • protein phosphorylation; • immune response; • transforming growth factor beta receptor signaling pathway; • ectoderm development; • dorsal/ventral axis specification; • positive regulation of pathway-restricted SMAD protein phosphorylation; • neural crest cell development; • stem cell maintenance; • pituitary gland development; • neural plate mediolateral regionalization; • signal transduction by protein phosphorylation; • lung development; • positive regulation of bone mineralization; • BMP signaling pathway; • hindlimb morphogenesis; • odontogenesis of dentin-containing tooth; • embryonic digit morphogenesis; • positive regulation of osteoblast differentiation; • positive regulation of transcription from RNA polymerase II promoter; • paraxial mesoderm structural organization; • lateral mesoderm development; • regulation of lateral mesodermal cell fate specification; • mesendoderm development; • embryonic organ development; • developmental growth; • positive regulation of epithelial cell proliferation; • negative regulation of neurogenesis; • palate development; • positive regulation of SMAD protein import into nucleus; • heart formation; • cellular response to BMP stimulus; • regulation of cellular senescence;
	Источники: Amigo / QuickGO

BMPR1A (англ. bone morphogenetic protein receptor, type IA, также CD292) — белок, кодируемый у человека геном BMPR1A.

Костные морфогенетические белки — семейство серин-треониновых трансмембранных протеинкиназ, включающее в себя два рецептора I типа (BMPR1A и BMPR1B), массой около 50—55 кДа, а также рецептор II типа BMPR2, около 70—80 кДа. К соответствующим типам относятся также активиновые рецепторы ACVR1 и ACVR2. Лиганды к этим белкам относятся к суперсемейству TGF-бета. Рецептор II типа связывается с лигандом в отсутствие рецептора I типа^[1].

Регуляция численности стволовых клеток путём подавления Wnt-сигнала
Участие в окостенении и дифференцировке клеток, в частности, на этапе гаструляции^[2]
Участие в процессах апоптоза
Участие в развитии адипоцитов

Локализация у человека: 10 хромосома, 10q22.3^[1].

Лиганды-агонисты: BMP2, BMP4, BMP6, BMP7, GDF6

Лиганды-антагонисты: хордин, ноггин

↑ ¹ ² bmp1a bone morphogenetic protein 1a [Danio rerio (zebrafish)] - Gene - NCBI (неопр.). www.ncbi.nlm.nih.gov. Дата обращения: 13 февраля 2016.
↑ Mishina Y., Starbuck M. W., Gentile M. A., Fukuda T., Kasparcova V., Seedor J. G., Hanks M. C., Amling M., Pinero G. J., Harada S., Behringer R. R. Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling // Journal of Biological Chemistry. — 2004. — Vol. 279, № 26. — P. 27560–27566. — doi:10.1074/jbc.M404222200.

[autogenerated1-1] ¹ ² bmp1a bone morphogenetic protein 1a [Danio rerio (zebrafish)] - Gene - NCBI (неопр.). www.ncbi.nlm.nih.gov. Дата обращения: 13 февраля 2016.

[2] Mishina Y., Starbuck M. W., Gentile M. A., Fukuda T., Kasparcova V., Seedor J. G., Hanks M. C., Amling M., Pinero G. J., Harada S., Behringer R. R. Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling // Journal of Biological Chemistry. — 2004. — Vol. 279, № 26. — P. 27560–27566. — doi:10.1074/jbc.M404222200.

[1]

[2]

BMPR1A

Костные морфогенетические белки

Функции BMPR1A

Локализация

Лиганды к BMPR1A

Примечания

Категории