Bcl-2

Bcl-2
Bcl-2
Доступные структуры
Доступные структуры
PDB	Поиск ортологов: PDBe RCSB
Список идентификаторов PDB
Список идентификаторов PDB
	1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN, 5AGW, 5AGX, 5FCG
Идентификаторы
Псевдонимы	BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, apoptosis regulator, BCL2 apoptosis regulator, Genes, bcl-2
Внешние ID	OMIM: 151430 MGI: 88138 HomoloGene: 527 GeneCards: BCL2
Расположение гена (человек)
Расположение гена (человек)
Хр.	18-я хромосома человека
Конец	63,320,128 bp
Расположение гена (Мышь)
Расположение гена (Мышь)
Хр.	1-я хромосома мыши
Конец	106,642,004 bp
Паттерн экспрессии РНК
Паттерн экспрессии РНК
	Наибольшая экспрессия в
	inferior olivary nucleus; ; trigeminal ganglion; ; internal globus pallidus; ; external globus pallidus; ; caput epididymis;
	н/д
	Дополнительные справочные данные
	Дополнительные справочные данные
Генная онтология
Генная онтология
Молекулярная функция	protein phosphatase binding; transcription factor binding; protein phosphatase 2A binding; channel inhibitor activity; гомодимеризация белка; channel activity; protease binding; связывание с белками плазмы; sequence-specific DNA binding; BH3 domain binding; связывание похожих белков; protein heterodimerization activity; ubiquitin protein ligase binding;
Компонент клетки	цитоплазма; цитозоль; ядерная мембрана; мембрана; митохондрия; клеточное ядро; mitochondrial membrane; миелиновая оболочка; mitochondrial outer membrane; Эндоплазматический ретикулум; pore complex; часть мембраны; внутренний компонент клетки; endoplasmic reticulum membrane; нуклеоплазма; protein-containing complex;
Биологический процесс	negative regulation of neuron apoptotic process; intrinsic apoptotic signaling pathway in response to oxidative stress; ureteric bud development; renal system process; рост органов; T cell differentiation in thymus; lymphocyte homeostasis; response to steroid hormone; positive regulation of catalytic activity; ear development; glomerulus development; post-embryonic development; cellular response to DNA damage stimulus; T cell homeostasis; negative regulation of ossification; negative regulation of G1/S transition of mitotic cell cycle; positive regulation of smooth muscle cell migration; regulation of protein localization; T cell differentiation; B cell lineage commitment; response to ischemia; regulation of mitochondrial membrane permeability; humoral immune response; defense response to virus; mesenchymal cell development; positive regulation of multicellular organism growth; морфогенез органа животных; developmental pigmentation; hair follicle morphogenesis; B cell differentiation; пролиферация; metanephros development; melanocyte differentiation; negative regulation of autophagy; positive regulation of neuron maturation; negative regulation of myeloid cell apoptotic process; cellular response to hypoxia; pigment granule organization; негативная регуляция пролиферации клеток; B cell receptor signaling pathway; cellular response to organic substance; regulation of apoptotic process; response to cytokine; cellular response to glucose starvation; regulation of protein stability; Оссификация; positive regulation of melanocyte differentiation; axon regeneration; нефрогенез; actin filament organization; thymus development; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of apoptotic signaling pathway; response to nicotine; развитие селезёнки; endoplasmic reticulum calcium ion homeostasis; positive regulation of skeletal muscle fiber development; response to oxidative stress; lymphoid progenitor cell differentiation; positive regulation of peptidyl-serine phosphorylation; CD8-positive, alpha-beta T cell lineage commitment; reactive oxygen species metabolic process; negative regulation of retinal cell programmed cell death; branching involved in ureteric bud morphogenesis; gland morphogenesis; positive regulation of cell growth; positive regulation of B cell proliferation; negative regulation of cell growth; response to gamma radiation; positive regulation of intrinsic apoptotic signaling pathway; response to toxic substance; морфогенез пищеварительного тракта; neuron apoptotic process; развитие яичек; regulation of protein heterodimerization activity; regulation of glycoprotein biosynthetic process; regulation of viral genome replication; женская беременность; negative regulation of mitochondrial depolarization; protein dephosphorylation; protein polyubiquitination; cellular calcium ion homeostasis; B cell homeostasis; behavioral fear response; oocyte development; regulation of cell-matrix adhesion; response to iron ion; negative regulation of cell migration; regulation of autophagy; positive regulation of developmental pigmentation; developmental growth; regulation of transmembrane transporter activity; ovarian follicle development; regulation of gene expression; negative regulation of calcium ion transport into cytosol; negative regulation of osteoblast proliferation; homeostasis of number of cells within a tissue; пигментация; response to radiation; regulation of catalytic activity; peptidyl-threonine phosphorylation; regulation of protein homodimerization activity; negative regulation of anoikis; response to hydrogen peroxide; T cell lineage commitment; cochlear nucleus development; leukocyte homeostasis; regulation of programmed cell death; regulation of calcium ion transport; axonogenesis; negative regulation of cellular pH reduction; response to glucocorticoid; regulation of cell cycle; regulation of mitochondrial membrane potential; melanin metabolic process; focal adhesion assembly; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; B cell proliferation; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; развитие иммунной системы; apoptotic mitochondrial changes; peptidyl-serine phosphorylation; regulation of nitrogen utilization; cell morphogenesis; позитивная регуляция пролиферации клеток; negative regulation of reactive oxygen species metabolic process; response to UV-B; regulation of developmental pigmentation; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; release of cytochrome c from mitochondria; negative regulation of mitotic cell cycle; extrinsic apoptotic signaling pathway in absence of ligand; апоптоз; трансмембранный транспорт; intrinsic apoptotic signaling pathway in response to DNA damage; биологический рост; cell-cell adhesion; cytokine-mediated signaling pathway; негативная регуляция апоптоза; гемопоэз; regulation of growth; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;
	Источники: Amigo, QuickGO
Ортологи
Ортологи
	596
	12043
	ENSG00000171791
	ENSMUSG00000057329
	P10415
	P10417
	NM_000633; NM_000657
	NM_009741; NM_177410
	NP_000624; NP_000648
	NP_033871; NP_803129
Смотреть (человек)	Смотреть (мышь)

Bcl-2
Bcl-2
Доступные структуры
Доступные структуры
PDB	Поиск ортологов: PDBe RCSB
Список идентификаторов PDB
Список идентификаторов PDB
	1G5M, 1GJH, 1YSW, 2O21, 2O22, 2O2F, 2W3L, 2XA0, 4AQ3, 4IEH, 4LVT, 4LXD, 4MAN, 5AGW, 5AGX, 5FCG
Идентификаторы
Псевдонимы	BCL2, Bcl-2, PPP1R50, B-cell CLL/lymphoma 2, apoptosis regulator, BCL2 apoptosis regulator, Genes, bcl-2
Внешние ID	OMIM: 151430 MGI: 88138 HomoloGene: 527 GeneCards: BCL2
Расположение гена (человек)
Расположение гена (человек)
Хр.	18-я хромосома человека
Конец	63,320,128 bp
Расположение гена (Мышь)
Расположение гена (Мышь)
Хр.	1-я хромосома мыши
Конец	106,642,004 bp
Паттерн экспрессии РНК
Паттерн экспрессии РНК
	Наибольшая экспрессия в
	inferior olivary nucleus; ; trigeminal ganglion; ; internal globus pallidus; ; external globus pallidus; ; caput epididymis;
	н/д
	Дополнительные справочные данные
	Дополнительные справочные данные
Генная онтология
Генная онтология
Молекулярная функция	protein phosphatase binding; transcription factor binding; protein phosphatase 2A binding; channel inhibitor activity; гомодимеризация белка; channel activity; protease binding; связывание с белками плазмы; sequence-specific DNA binding; BH3 domain binding; связывание похожих белков; protein heterodimerization activity; ubiquitin protein ligase binding;
Компонент клетки	цитоплазма; цитозоль; ядерная мембрана; мембрана; митохондрия; клеточное ядро; mitochondrial membrane; миелиновая оболочка; mitochondrial outer membrane; Эндоплазматический ретикулум; pore complex; часть мембраны; внутренний компонент клетки; endoplasmic reticulum membrane; нуклеоплазма; protein-containing complex;
Биологический процесс	negative regulation of neuron apoptotic process; intrinsic apoptotic signaling pathway in response to oxidative stress; ureteric bud development; renal system process; рост органов; T cell differentiation in thymus; lymphocyte homeostasis; response to steroid hormone; positive regulation of catalytic activity; ear development; glomerulus development; post-embryonic development; cellular response to DNA damage stimulus; T cell homeostasis; negative regulation of ossification; negative regulation of G1/S transition of mitotic cell cycle; positive regulation of smooth muscle cell migration; regulation of protein localization; T cell differentiation; B cell lineage commitment; response to ischemia; regulation of mitochondrial membrane permeability; humoral immune response; defense response to virus; mesenchymal cell development; positive regulation of multicellular organism growth; морфогенез органа животных; developmental pigmentation; hair follicle morphogenesis; B cell differentiation; пролиферация; metanephros development; melanocyte differentiation; negative regulation of autophagy; positive regulation of neuron maturation; negative regulation of myeloid cell apoptotic process; cellular response to hypoxia; pigment granule organization; негативная регуляция пролиферации клеток; B cell receptor signaling pathway; cellular response to organic substance; regulation of apoptotic process; response to cytokine; cellular response to glucose starvation; regulation of protein stability; Оссификация; positive regulation of melanocyte differentiation; axon regeneration; нефрогенез; actin filament organization; thymus development; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of apoptotic signaling pathway; response to nicotine; развитие селезёнки; endoplasmic reticulum calcium ion homeostasis; positive regulation of skeletal muscle fiber development; response to oxidative stress; lymphoid progenitor cell differentiation; positive regulation of peptidyl-serine phosphorylation; CD8-positive, alpha-beta T cell lineage commitment; reactive oxygen species metabolic process; negative regulation of retinal cell programmed cell death; branching involved in ureteric bud morphogenesis; gland morphogenesis; positive regulation of cell growth; positive regulation of B cell proliferation; negative regulation of cell growth; response to gamma radiation; positive regulation of intrinsic apoptotic signaling pathway; response to toxic substance; морфогенез пищеварительного тракта; neuron apoptotic process; развитие яичек; regulation of protein heterodimerization activity; regulation of glycoprotein biosynthetic process; regulation of viral genome replication; женская беременность; negative regulation of mitochondrial depolarization; protein dephosphorylation; protein polyubiquitination; cellular calcium ion homeostasis; B cell homeostasis; behavioral fear response; oocyte development; regulation of cell-matrix adhesion; response to iron ion; negative regulation of cell migration; regulation of autophagy; positive regulation of developmental pigmentation; developmental growth; regulation of transmembrane transporter activity; ovarian follicle development; regulation of gene expression; negative regulation of calcium ion transport into cytosol; negative regulation of osteoblast proliferation; homeostasis of number of cells within a tissue; пигментация; response to radiation; regulation of catalytic activity; peptidyl-threonine phosphorylation; regulation of protein homodimerization activity; negative regulation of anoikis; response to hydrogen peroxide; T cell lineage commitment; cochlear nucleus development; leukocyte homeostasis; regulation of programmed cell death; regulation of calcium ion transport; axonogenesis; negative regulation of cellular pH reduction; response to glucocorticoid; regulation of cell cycle; regulation of mitochondrial membrane potential; melanin metabolic process; focal adhesion assembly; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; B cell proliferation; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; развитие иммунной системы; apoptotic mitochondrial changes; peptidyl-serine phosphorylation; regulation of nitrogen utilization; cell morphogenesis; позитивная регуляция пролиферации клеток; negative regulation of reactive oxygen species metabolic process; response to UV-B; regulation of developmental pigmentation; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; extrinsic apoptotic signaling pathway via death domain receptors; release of cytochrome c from mitochondria; negative regulation of mitotic cell cycle; extrinsic apoptotic signaling pathway in absence of ligand; апоптоз; трансмембранный транспорт; intrinsic apoptotic signaling pathway in response to DNA damage; биологический рост; cell-cell adhesion; cytokine-mediated signaling pathway; негативная регуляция апоптоза; гемопоэз; regulation of growth; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;
	Источники: Amigo, QuickGO
Ортологи
Ортологи
	596
	12043
	ENSG00000171791
	ENSMUSG00000057329
	P10415
	P10417
	NM_000633; NM_000657
	NM_009741; NM_177410
	NP_000624; NP_000648
	NP_033871; NP_803129
Смотреть (человек)	Смотреть (мышь)

Регулятор апоптоза Bcl-2 (англ. Apoptosis regulator Bcl-2) — внутриклеточный белковый фактор, основной представитель семейства Bcl-2.

Подавляет апоптоз во многих клеточных системах, включая лимфогематопоэтические и нейрональные клетки. Регулирует клеточную смерть, контролируя проницаемость митохондриальной мембраны. Ингибирует каспазы за счёт предотвращения выхода цитохрома c из митохондрий и/или за счёт связывания фактора, активирующего апоптоз — APAF1.

Лабораторные мыши, у которых ген BCL2 искусственно инактивирован, характеризуются замедленным ростом и умирают вскоре после рождения. Гематопоэз у таких мышей протекает нормально на ранних стадиях, но тимус и селезёнка подвергаются ярко выраженной апоптотической инволюции. Также у животных развивается почечная недостаточность и нарушается синтез меланина^[6].

BH3-миметик венетоклакс является ингибитором Bcl-2 и используется в терапии хронического лимфолейкоза. Препарат блокирует связывание Bcl-2 с проапоптотическими белками Bax и Bak.

APAF1

База данных по белкам семейства Bcl-2.

[1]

[2]

[3]

[4]

[6]

Bcl-2

Функции

Клиническое применение

См. также

Ссылки

Примечания