ANAPC4

Субъединица комплекса стимуляции анафазы 4
Функция	• ubiquitin-protein transferase activity; • protein binding; • protein phosphatase binding;
Компонент клетки	• nucleus; • nucleoplasm; • anaphase-promoting complex; • cytosol;
Биологический процесс	• G2/M transition of mitotic cell cycle; • mitotic anaphase; • mitotic cell cycle; • ubiquitin-dependent protein catabolic process; • mitotic nuclear division; • mitotic spindle assembly checkpoint; • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; • positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; • protein K11-linked ubiquitination;
	Источники: Amigo / QuickGO

Субъединица комплекса стимуляции анафазы 4
	0
Идентификаторы
Функция	• ubiquitin-protein transferase activity; • protein binding; • protein phosphatase binding;
Компонент клетки	• nucleus; • nucleoplasm; • anaphase-promoting complex; • cytosol;
Биологический процесс	• G2/M transition of mitotic cell cycle; • mitotic anaphase; • mitotic cell cycle; • ubiquitin-dependent protein catabolic process; • mitotic nuclear division; • mitotic spindle assembly checkpoint; • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; • positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; • protein K11-linked ubiquitination;
	Источники: Amigo / QuickGO

Субъединица комплекса стимуляции анафазы 4
	0
Идентификаторы
Функция	• ubiquitin-protein transferase activity; • protein binding; • protein phosphatase binding;
Компонент клетки	• nucleus; • nucleoplasm; • anaphase-promoting complex; • cytosol;
Биологический процесс	• G2/M transition of mitotic cell cycle; • mitotic anaphase; • mitotic cell cycle; • ubiquitin-dependent protein catabolic process; • mitotic nuclear division; • mitotic spindle assembly checkpoint; • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; • negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; • positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; • regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; • protein K11-linked ubiquitination;
	Источники: Amigo / QuickGO

Субъединица комплекса стимуляции анафазы 4 (англ. Anaphase-promoting complex subunit 4) — фермент, кодируемый у человека геном ANAPC4^[1]^[2].

Большой белковый комплекс, называемый комплексом стимуляции анафазы (APK), или циклосомой, способствует переходу от метафазы к анафазе, убиквитинизируя свои специфические субстраты, такие как митотические циклины и ингибиторы анафазы, которые впоследствии деградируются в 26S протеасоме. Биохимические исследования показали, что у позвоночных APC содержит восемь субъединиц. Состав APC высоко консервативен у всех организмов от дрожжей до человека. Точная функция продукта этого гена неизвестна^[2].

ANAPC4, как было выявлено, взаимодействует с ANAPC1^[3]^[4], ANAPC5^[3], CDC27^[3]^[5] и ANAPC7^[3].

↑ Tekolf W.A., Biddison W.E., Aster R.D., Shaw S. Two subgroups of HLA Bw44 defined by cell-mediated lympholysis that differ in Bw44 expression on platelets and in patterns of genetic linkage disequilibrium (англ.) // Journal of Immunology : journal. — 1982. — October (vol. 129, no. 4). — P. 1474—1478. — PMID 6180011.
↑ ¹ ² Entrez Gene: ANAPC4 anaphase promoting complex subunit 4 (неопр.).
↑ ¹ ² ³ ⁴ Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael. TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 (англ.) // Curr. Biol. : journal. — England, 2003. — September (vol. 13, no. 17). — P. 1459—1468. — ISSN 0960-9822. — doi:10.1016/S0960-9822(03)00581-5. — PMID 12956947.
↑ Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M. Characterization of vertebrate cohesin complexes and their regulation in prophase (англ.) // Journal of Cell Biology : journal. — UNITED STATES, 2000. — November (vol. 151, no. 4). — P. 749—762. — ISSN 0021-9525. — doi:10.1083/jcb.151.4.749. — PMID 11076961. — PMC 2169443.
↑ Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — UNITED STATES, 2000. — August (vol. 97, no. 16). — P. 8973—8978. — ISSN 0027-8424. — doi:10.1073/pnas.97.16.8973. — PMID 10922056. — PMC 16806.

Bonaldo M.F., Lennon G., Soares M.B. Normalization and subtraction: two approaches to facilitate gene discovery. (англ.) // Genome Research : journal. — 1997. — Vol. 6, no. 9. — P. 791—806. — doi:10.1101/gr.6.9.791. — PMID 8889548.
Yu H., Peters J.M., King R.W. et al. Identification of a cullin homology region in a subunit of the anaphase-promoting complex. (англ.) // Science : journal. — 1998. — Vol. 279, no. 5354. — P. 1219—1222. — doi:10.1126/science.279.5354.1219. — PMID 9469815.
Grossberger R., Gieffers C., Zachariae W. et al. Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex. (англ.) // J. Biol. Chem. : journal. — 1999. — Vol. 274, no. 20. — P. 14500—14507. — doi:10.1074/jbc.274.20.14500. — PMID 10318877.
Gieffers C., Peters B.H., Kramer E.R. et al. Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons. (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1999. — Vol. 96, no. 20. — P. 11317—11322. — doi:10.1073/pnas.96.20.11317. — PMID 10500174. — PMC 18031.
Gmachl M., Gieffers C., Podtelejnikov A.V. et al. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex. (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2000. — Vol. 97, no. 16. — P. 8973—8978. — doi:10.1073/pnas.97.16.8973. — PMID 10922056. — PMC 16806.
Strausberg R.L., Feingold E.A., Grouse L.H. et al. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 2003. — Vol. 99, no. 26. — P. 16899—16903. — doi:10.1073/pnas.242603899. — PMID 12477932. — PMC 139241.
Vodermaier H.C., Gieffers C., Maurer-Stroh S. et al. TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1. (англ.) // Curr. Biol. : journal. — 2004. — Vol. 13, no. 17. — P. 1459—1468. — doi:10.1016/S0960-9822(03)00581-5. — PMID 12956947.
Kraft C., Herzog F., Gieffers C. et al. Mitotic regulation of the human anaphase-promoting complex by phosphorylation. (англ.) // The EMBO Journal : journal. — 2004. — Vol. 22, no. 24. — P. 6598—6609. — doi:10.1093/emboj/cdg627. — PMID 14657031. — PMC 291822.
Johnson J.M., Castle J., Garrett-Engele P. et al. Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. (англ.) // Science : journal. — 2004. — Vol. 302, no. 5653. — P. 2141—2144. — doi:10.1126/science.1090100. — PMID 14684825.
Ota T., Suzuki Y., Nishikawa T. et al. Complete sequencing and characterization of 21,243 full-length human cDNAs. (англ.) // Nat. Genet. : journal. — 2004. — Vol. 36, no. 1. — P. 40—5. — doi:10.1038/ng1285. — PMID 14702039.

[pmid6180011-1] Tekolf W.A., Biddison W.E., Aster R.D., Shaw S. Two subgroups of HLA Bw44 defined by cell-mediated lympholysis that differ in Bw44 expression on platelets and in patterns of genetic linkage disequilibrium (англ.) // Journal of Immunology : journal. — 1982. — October (vol. 129, no. 4). — P. 1474—1478. — PMID 6180011.

[entrez-2] ¹ ² Entrez Gene: ANAPC4 anaphase promoting complex subunit 4 (неопр.).

[pmid12956947-3] ¹ ² ³ ⁴ Vodermaier, Hartmut C; Gieffers, Christian; Maurer-Stroh, Sebastian; Eisenhaber, Frank; Peters, Jan-Michael. TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1 (англ.) // Curr. Biol. : journal. — England, 2003. — September (vol. 13, no. 17). — P. 1459—1468. — ISSN 0960-9822. — doi:10.1016/S0960-9822(03)00581-5. — PMID 12956947.

[pmid11076961-4] Sumara, I; Vorlaufer E; Gieffers C; Peters B H; Peters J M. Characterization of vertebrate cohesin complexes and their regulation in prophase (англ.) // Journal of Cell Biology : journal. — UNITED STATES, 2000. — November (vol. 151, no. 4). — P. 749—762. — ISSN 0021-9525. — doi:10.1083/jcb.151.4.749. — PMID 11076961. — PMC 2169443.

[pmid10922056-5] Gmachl, M; Gieffers C; Podtelejnikov A V; Mann M; Peters J M. The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — UNITED STATES, 2000. — August (vol. 97, no. 16). — P. 8973—8978. — ISSN 0027-8424. — doi:10.1073/pnas.97.16.8973. — PMID 10922056. — PMC 16806.

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ANAPC4

Взаимодействия

Примечания

Литература

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