GNB2L1

Нуклеотидо-связывающий белок гуанина(G-белок), подобный бета полипептиду 2, 1
Нуклеотидо-связывающий белок гуанина(G-белок), подобный бета полипептиду 2, 1
Доступные структуры
PDB
	Список идентификаторов PDB 3J3A, 4AOW
Идентификаторы
Символ
Внешние ID
Функция	• protein kinase C binding; • receptor binding; • protein binding; • ion channel inhibitor activity; • cysteine-type endopeptidase activator activity involved in apoptotic process; • enzyme binding; • protein phosphatase binding; • protein tyrosine kinase inhibitor activity; • receptor tyrosine kinase binding; • protein complex scaffold; • SH2 domain binding; • protein homodimerization activity; • poly(A) RNA binding;
Компонент клетки	• phagocytic cup; • nucleus; • cytoplasm; • mitochondrion; • cytosol; • cytoskeleton; • small ribosomal subunit; • dendrite; • midbody; • neuronal cell body; • perikaryon; • perinuclear region of cytoplasm; • extracellular vesicular exosome;
Биологический процесс	• positive regulation of protein phosphorylation; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • cell cycle; • gastrulation; • negative regulation of gene expression; • viral process; • negative regulation of translation; • negative regulation of Wnt signaling pathway; • negative regulation of cell growth; • positive regulation of cell migration; • positive regulation of cAMP catabolic process; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • positive regulation of protein homooligomerization; • regulation of protein localization; • positive regulation of apoptotic process; • negative regulation of neuron apoptotic process; • positive regulation of GTPase activity; • rhythmic process; • negative regulation of phagocytosis; • regulation of cell division; • positive regulation of cyclic-nucleotide phosphodiesterase activity; • regulation of cell cycle; • negative regulation of protein kinase B signaling; • positive regulation of mitochondrial depolarization; • negative regulation of protein tyrosine kinase activity; • regulation of establishment of protein localization to plasma membrane; • negative regulation of hydrogen peroxide-mediated programmed cell death; • regulation of establishment of cell polarity; • positive regulation of gastrulation; • positive regulation of intrinsic apoptotic signaling pathway;
	Источники: Amigo / QuickGO
Ортологи

Нуклеотидо-связывающий белок гуанина(G-белок), подобный бета полипептиду 2, 1
Нуклеотидо-связывающий белок гуанина(G-белок), подобный бета полипептиду 2, 1
Доступные структуры
PDB
	Список идентификаторов PDB 3J3A, 4AOW
Идентификаторы
Символ
Внешние ID
Функция	• protein kinase C binding; • receptor binding; • protein binding; • ion channel inhibitor activity; • cysteine-type endopeptidase activator activity involved in apoptotic process; • enzyme binding; • protein phosphatase binding; • protein tyrosine kinase inhibitor activity; • receptor tyrosine kinase binding; • protein complex scaffold; • SH2 domain binding; • protein homodimerization activity; • poly(A) RNA binding;
Компонент клетки	• phagocytic cup; • nucleus; • cytoplasm; • mitochondrion; • cytosol; • cytoskeleton; • small ribosomal subunit; • dendrite; • midbody; • neuronal cell body; • perikaryon; • perinuclear region of cytoplasm; • extracellular vesicular exosome;
Биологический процесс	• positive regulation of protein phosphorylation; • activation of cysteine-type endopeptidase activity involved in apoptotic process; • cell cycle; • gastrulation; • negative regulation of gene expression; • viral process; • negative regulation of translation; • negative regulation of Wnt signaling pathway; • negative regulation of cell growth; • positive regulation of cell migration; • positive regulation of cAMP catabolic process; • positive regulation of proteasomal ubiquitin-dependent protein catabolic process; • positive regulation of protein homooligomerization; • regulation of protein localization; • positive regulation of apoptotic process; • negative regulation of neuron apoptotic process; • positive regulation of GTPase activity; • rhythmic process; • negative regulation of phagocytosis; • regulation of cell division; • positive regulation of cyclic-nucleotide phosphodiesterase activity; • regulation of cell cycle; • negative regulation of protein kinase B signaling; • positive regulation of mitochondrial depolarization; • negative regulation of protein tyrosine kinase activity; • regulation of establishment of protein localization to plasma membrane; • negative regulation of hydrogen peroxide-mediated programmed cell death; • regulation of establishment of cell polarity; • positive regulation of gastrulation; • positive regulation of intrinsic apoptotic signaling pathway;
	Источники: Amigo / QuickGO
Ортологи

Гуанидин нуклеотид связывающая субъединица бета-2 (англ. Guanine nucleotide-binding protein subunit beta-2-like 1) также известная как Рецептор для активаци C 1 или RACK1 (англ. Receptor for activated C kinase) — белок массой 32 кДа, кодируемый у человека геном GNB2L1 ^[1]^[2].

GNB2L1, как было выявлено, взаимодействует с:

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Disatnik M.H., Hernandez-Sotomayor S.M., Jones G. et al. Phospholipase C-gamma 1 binding to intracellular receptors for activated protein kinase C (англ.) // Proceedings of the National Academy of Sciences of the United States of America : journal. — 1994. — Vol. 91, no. 2. — P. 559—563. — doi:10.1073/pnas.91.2.559. — PMID 8290562. — PMC 42988.
Suzuki Y., Yoshitomo-Nakagawa K., Maruyama K. et al. Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library (англ.) // Gene (журнал) : journal. — Elsevier, 1997. — Vol. 200, no. 1—2. — P. 149—156. — doi:10.1016/S0378-1119(97)00411-3. — PMID 9373149.
Liliental J., Chang D.D. Rack1, a receptor for activated protein kinase C, interacts with integrin beta subunit (англ.) // J. Biol. Chem. : journal. — 1998. — Vol. 273, no. 4. — P. 2379—2383. — doi:10.1074/jbc.273.4.2379. — PMID 9442085.
Chang B.Y., Conroy K.B., Machleder E.M., Cartwright C.A. RACK1, a receptor for activated C kinase and a homolog of the beta subunit of G proteins, inhibits activity of src tyrosine kinases and growth of NIH 3T3 cells (англ.) // Molecular and Cellular Biology : journal. — 1998. — Vol. 18, no. 6. — P. 3245—3256. — PMID 9584165. — PMC 108906.
Rietzler M., Bittner M., Kolanus W. et al. The human WD repeat protein WAIT-1 specifically interacts with the cytoplasmic tails of beta7-integrins (англ.) // J. Biol. Chem. : journal. — 1998. — Vol. 273, no. 42. — P. 27459—27466. — doi:10.1074/jbc.273.42.27459. — PMID 9765275.
Shimohama S., Kamiya S., Taniguchi T., Kimura J. Intracellular receptors for activated C-kinase in the postmortem human brain: no alteration in Alzheimer disease (англ.) // Alzheimer Disease and Associated Disorders : journal. — 1999. — Vol. 12, no. 4. — P. 384—386. — doi:10.1097/00002093-199812000-00022. — PMID 9876970.
Yarwood S.J., Steele M.R., Scotland G. et al. The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform (англ.) // J. Biol. Chem. : journal. — 1999. — Vol. 274, no. 21. — P. 14909—14917. — doi:10.1074/jbc.274.21.14909. — PMID 10329691.
Ron D., Jiang Z., Yao L. et al. Coordinated movement of RACK1 with activated betaIIPKC (англ.) // J. Biol. Chem. : journal. — 1999. — Vol. 274, no. 38. — P. 27039—27046. — doi:10.1074/jbc.274.38.27039. — PMID 10480917.
Geijsen N., Spaargaren M., Raaijmakers J.A. et al. Association of RACK1 and PKCbeta with the common beta-chain of the IL-5/IL-3/GM-CSF receptor (англ.) // Oncogene (журнал) : journal. — 1999. — Vol. 18, no. 36. — P. 5126—5130. — doi:10.1038/sj.onc.1202896. — PMID 10490850.
Smith P.R., de Jesus O., Turner D. et al. Structure and coding content of CST (BART) family RNAs of Epstein-Barr virus (англ.) // Journal of Virology : journal. — 2000. — Vol. 74, no. 7. — P. 3082—3092. — doi:10.1128/JVI.74.7.3082-3092.2000. — PMID 10708423. — PMC 111807.
Ellis J.H., Ashman C., Burden M.N. et al. GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28 (англ.) // Journal of Immunology : journal. — 2000. — Vol. 164, no. 11. — P. 5805—5814. — doi:10.4049/jimmunol.164.11.5805. — PMID 10820259.
Croze E., Usacheva A., Asarnow D. et al. Receptor for activated C-kinase (RACK-1), a WD motif-containing protein, specifically associates with the human type I IFN receptor (англ.) // Journal of Immunology : journal. — 2000. — Vol. 165, no. 9. — P. 5127—5132. — doi:10.4049/jimmunol.165.9.5127. — PMID 11046044.
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GNB2L1

Взаимодействия

Примечания

Литература